The Comayagua Department is located in the central part of the country. It has a territorial area of 5,124 km².
During almost the entire Colonial Period, Comayagua was the most important political center of the province and even part of the post-independence period. It ceased to be the capital on October 30, 1880 and was moved to Tegucigalpa.
Limits:
- North: departments of Cortés and Yoro;
- Sur: departments of La Paz and Francisco Morazán;
- East: department of Francisco Morazán;
- West: departments of Intibucá and Santa Bárbara.



